Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 457065, 7 pages
Methodology Report

An Experimental Model for Resistance Exercise in Rodents

1Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, Cidade Universitária, 05508-030 São Paulo, SP, Brazil
2Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-030 São Paulo, SP, Brazil

Received 6 August 2011; Revised 21 October 2011; Accepted 28 November 2011

Academic Editor: Leon Spicer

Copyright © 2012 Humberto Nicastro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to develop an equipment and system of resistance exercise (RE), based on squat-type exercise for rodents, with control of training variables. We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal. With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction). Furthermore, it is possible to perform muscle function tests in vivo within the context of the exercise proposed and control variables such as intensity, volume (sets and repetitions), and exercise session length, rest interval between sets and repetitions, and concentric strength. Based on the experiments conducted, we demonstrated that the model proposed is able to perform more specific control of other RE variables, especially rest interval between sets and repetitions, and encourages the animal to exercise through short-term energy restriction and “disturbing” stimulus that do not promote alterations in body weight. Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.