Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape

<table>Effects of adenosine produced by CD39+/CD73+ cells on target cells. Cancer cells, Tregs, Th17, and MDSCs could produce adenosine through degradation of ATP/ADP by CD39 and CD73. Then adenosine binds on target cells, such as immune cells, cancer cells, or endothelial cells and modifies their activity.</table>

BioMed Research International

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Figure 1

Figure 1: Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape 