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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 483969, 9 pages
Review Article

Protein Palmitoylation and Pathogenesis in Apicomplexan Parasites

Laboratorio de Parasitologia Molecular, Instituto Tecnológico de Chascomús (IIBINTECH), CONICET-Universidad Nacional de General San Martín, Intendente Marino Km 8,2, P.O. Box 164, Chascomús, B7130IWA Buenos Aires, Argentina

Received 23 May 2012; Revised 18 July 2012; Accepted 24 July 2012

Academic Editor: Andrea Silvana Rópolo

Copyright © 2012 Maria Martha Corvi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Apicomplexan parasites comprise a broad variety of protozoan parasites, including Toxoplasma gondii, Plasmodium, Eimeria, and Cryptosporidium species. Being intracellular parasites, the success in establishing pathogenesis relies in their ability to infect a host-cell and replicate within it. Protein palmitoylation is known to affect many aspects of cell biology. Furthermore, palmitoylation has recently been shown to affect important processes in T. gondii such as replication, invasion, and gliding. Thus, this paper focuses on the importance of protein palmitoylation in the pathogenesis of apicomplexan parasites.