|
| Reference | Patient details | Intervention | Outcome | |
| Age | Concurrent conditions/
treatments | Plant/
substance | Route1 | Duration2 | Dose3 | Adverse events | Acute management | Outcome4 | Causality5 | Comments |
|
| Blaiss et al. 1987 [53] | 21 | In the past allergic rhinitis to numerous inhalant allergens: grasses, milds, ragweed, and dust mite. Immunotherapy to grass and dust allergens stopped a year prior to reported events | Cabbage (in coleslaw) | Oral | 2 acute ingestions | Not specified | Anaphylaxis: pain and swelling in mouth and throat with difficult breathing. Swelling of lip, tongue, soft palate. No diffuse urticaria, wheezing or hypotension | Subcutaneous epinephrine, discharged on oral antihistamines and steroids | Full resolution | Certainly | Skin test also revealed allergy to mustard, cauliflower, and broccoli. Reexposure to coleslaw via oral ingestion after 2 weeks triggered same symptoms |
|
| Brito et al. 2001 [54] | 29 and 37 | Not given | Diplotaxis erucoides (wall rocket) pollen | Respiratory | 2 months every year | NA | Patient 1: rhinoconjunctivitis
Patient 2: rhinoconjunctivitis and asthma. Patients were tested and found to be allergic to Diplotaxis erucoides pollen | | Not mentioned | Likely | Occupational exposure |
|
| Compes et al. 2007 [55] | 38 | Ex-smoker, with a personal history of house dust mite allergic rhinitis and asthma, and a family history of atopy | Turnip seeds | Topical and respiratory | Chronic (exact duration not mentioned) | NA | Rhinitis and asthma. Patient was tested and found to be allergic to turnip seeds | Not mentioned | Not mentioned | Possibly | Bird fancier. Patient was also found to be allergic to avian antigens |
|
| Caldan 1981 [56] | 28 | Eczema and hay fever. In the past contact with other vegetables caused itching | Cabbage | Topical | Not reported (unclear whether chronic eczema is related to cabbage exposure) | NA | Contact urticaria. Patch test revealed allergy to “green leaves” (cabbage and Brusselss sprouts) | Not mentioned | Not mentioned | Possibly | Paper lacks many details regarding both urticaria and eczema |
|
| Chakrabarti et al. 2003 [57] | 56 | 3-year history of severe eczema and recurrent blisters on palms | Broccoli | Topical | Chronic (exact duration not mentioned) | NA | Allergic contact dermatitis (worsening of eczema) | Subcutaneous epinephrine, discharged on oral antihistamines and steroids | Partial resolution: eczema improved upon avoidance of topical contact with broccoli and other vegetables | Possibly | Patient refused patch tests to other vegetables, but it is possible that she is allergic not only to broccoli |
|
| Dannaker et al. 1987 [58] | 38 | 2 year history of hand dermatitis; 6 months history of dryness and scaling at angles of mouth (Unclear whether her hand dermatitis is related to mustard exposure) | Mustard in salad dressings | Topical | Chronic, for the past 3 years | NA | Acute episode of allergic contact dermatitis | Not mentioned | Not mentioned | Possibly | Occupational exposure |
|
| Di Giacomo et al. 1998 [59] | 48 | Not given | Oilseed rape flour | Respiratory | Chronic (exact duration not mentioned) | NA | Episodes of asthma and rhinoconjunctivitis Allergy tests showed that skin prick tests were only mildly positive for oilseed rape flour, and the peak respiratory flow only slightly decreased during exposure | Not mentioned | Not mentioned | Possibly | Occupational exposure |
|
| Hernandez et al. 2005 [60] | 70 | Allergies to some fruit and nuts, seasonal allergic rhinoconjunctivitis | Cauliflower | Oral | Acute ingestion | Not specified | Oropharyngeal itching, facial and hand swelling, severe bronchospasm | Required emergency room consult | Full resolution | Possibly | No details of what other components the dish included |
|
| Jorro et al. 1995 [61] | 43, 17, and 19 | Patient 1: history of IgE-dependent rhinitis since childhood; urticaria angioedema episodes related with shellfish. Patient 2: history of IgE-dependent asthma and rhinitis and urticaria to latex. Patient 3: history of IgE-dependent rhinitis | Mustard sauce | Oral | Acute ingestions | Not specified | Patient 1: episodes of pruritus, swelling of tongue, dysphagia, dysphonia, facial edema, and progressive upper respiratory difficulty. On one occasion, he experienced hypotension, and on another urticaria and palpebral edema. Patient 2: episodes of pruritus, swelling of lips and tongue, and edema. Patient 3: dysphonia, dysphagia, progressive upper respiratory difficulty, and generalized urticaria. Upon allergy testing, patients were found to be allergic to mustard | Not mentioned | Full resolution | Likely | None |
|
| Lingelbach et al. 2003 [62] | 40 | For the past 11 years: episodes of exercise-induced anaphylaxis after eating, once or twice a year | Cabbage and mustard | Oral | Acute ingestions | NA | Anaphylaxis induced by exercise after ingestion of cabbage or mustard | IV adrenaline, antihistamine, and corticosteroids | Full resolution | Likely | Patient was also found to be allergic to other foods |
|
| Meding 1985 [63] | 40 | Vesicular hand eczema for the past 9 years, sometimes worsened for no clear reason, and also after every mustard ingestion | Mustard and rapeseed | Oral (however, allergy testing was topical) | Acute ingestions | Not specified | Vesicular episodes (worsening of eczema). Positive skin prick test to crushed seeds of rapeseed | Not mentioned | Partial resolution: eczema improved upon avoidance of mustard and rapeseed | Possibly | Apart from ingestion, patient was also occupationally exposed to rapeseed |
|
| Pasricha et al. 1985 [64] | 35 and 47 | Patient 1 had suffered from dermatitis ever since she was 15, which worsened when handling cattle food. Patient 2: itching and erythematous papules for the past 1.5 years, for which she was treated | Patient 1: mustard; Patient 2: mustard khal | Topical | Chronic (exact duration not mentioned) | NA | Patient 1: itching and erythmatous papular lesions on forearms, arms, neck, forehead, ear lobules, and sides of face for the past 8 months. Patient 2: itching and erythmatous papules on forearms, forehead, cheeks, ear lobules, neck, and dorsum of feet for the past 1.5 years. Upon allergy testing, patient 1 found to be allergic to mustard, jowar flour, and wheat flour. Patient 2 found to be allergic to mustard khal and maize | Not mentioned (it is mentioned that treatment was given, but no further details are provided) | Improved with treatment, but authors do not mention what happens when not exposed | Possibly (patient 1), unlikely (patient 2) | Patient 1 had been using mustard oil for years and only lately did she start experiencing adverse event. Patient 2 did not report any exposure to mustard |
|
| Quirce et al. 2005 [65] | 41 | Allergic rhinoconjunctivitis to pollen. For past 7 years: episodes of ocular and nasal itching, sneezing, watery nose, tearing, dry cough, chest tightness, and dyspnea after inhaling cauliflower or cabbage vapors | Cabbage | Oral | Acute ingestion | Not specified | Generalized urticaria, facial and oropharyngeal angioedema. Upon allergy testing (with cabbage or cauliflower): severe rhinoconjunctivitis and an early asthmatic reaction | Required emergency room consult | Full resolution | Possibly | Occupational exposure |
|
| Rosenberg and Gervais 1986 [66] | 42 and 34 | Patient 1: asthma triggered by isocyanate paint. Patient 2: ex-smoker, asthma triggered by isocyanate paint | Patient 1: mustard and horseradish. Patient 2: mustard, radish, turnip | Oral | Acute ingestions | Not specified | Patient 1: face flushing, asthma attack. Patient 2: asthma attack | Patient 1: not mentioned; Patient 2: hospitalized, treated w/theophylline | Full resolution. In patient 2: recurrence when eating mustard/radish | Likely | Occupational exposure. No testing done for food allergies in either patients |
|
| Sanchez-Guerrero and Escudero 1998 [67] | 36 and 54 | Patient 1: for past 7 years: pruritus, erythema, vesicles, fissures, and peeling in both hands, as well as facial angioedema, within 6–8 h after handling broccoli. Patient 2: asthma; in past 4 years, papules and vesicles in both hands and eyelids 24–36 hours after exposure to cauliflower or broccoli | Broccoli or cauliflower | Topical | Chronic (exact duration not mentioned) | NA | Patient 1: acute episodes of contact dermatitis after handling broccoli; Patient 2: acute episodes of contact dermatitis after handling broccoli or cauliflower | Not mentioned | Patient 1: full resolution after avoiding broccoli. Patient 2: no resolution even when avoids allergens | Possibly | Occupational exposure |
|
| Schulze and Wollina 2003 [68] | 19 | Not given | Mustard (sauce and oil) | Oral and topical | varies (acute to chronic) | Not specified | At 4 years of age-topical exposure caused eye lacrimation and cauterization, and dyspnea. Upon ingestion at age of 19: angioedema and bronchospasm | Topical and oral antihistamines | Not mentioned | Possibly | Some mustard allergy tests were positive but rubbing test was negative. Cross-reactivity with other Brassica |
|
| Suh et al. 1998 [69] | 43 | Smoker; cough and chest pain | Oilseed rape dust | Respiratory | Chronic | NA | Aggravation of cough and chest pain | Not mentioned | Not mentioned | Possibly | Occupational exposure; allergy testing not performed |
|
| Valero et al. 1995 [70] | 34, 31, 25, 52, and 33 | Patient 1: house dust allergy. Patient 2: seasonal rhinitis. Patient 3: peach allergy; seasonal rhinitis; familial atopy. Patient 4: seasonal rhinoconjuctivitis and bronchial asthma, family pollen allergy. | Mustard sauce or mustard pollen | Oral and respiratory | Acute (ingestion) to seasonal (pollen inhalation) | Not specified | Patient 1–3: urticaria, facial edema, rhinoconjunctivitis/rhinitis. Patient 4: facial edema, bronchospasm, rhinitis. Patient 5: urticaria, facial edema, and bronchospasm. All found to be allergic to mustard | Not mentioned | Full resolution | Possibly | None |
|
| van Ketel et al. 1975 [71] | 43 | Eczema in past 10 years | Cauliflower | Topical | Chronic (exact duration not mentioned) | NA | Aggravation of eczema. Upon allergy testing was found allergic to both cauliflower and other Brassica: Brusselss sprouts and red cabbage | Not mentioned | Not mentioned | Possibly | Occupational exposure. Aggravation of eczema also occurs after contact with onions, tulip bulbs, rubber gloves, and pesticides, but to a lesser extent |
|
| Widstrom and Johansson 1986 [72] | 25 | As a child, severe atopic dermatitis, rhinitis and swelling of throat in reaction to fish or egg. Currently, rhinitis when exposed to cats or dogs | Mustard (in mustard sauce or mayonnaise) | Oral | Acute ingestions | Not specified | Acute episodes of urticaria and angioneurotic edema of face and neck. Upon allergy testing was found to be allergic to mustard | Not mentioned | Full resolution | Possibly | None |
|
| Zawar 2005 [73] | 25 | Healthy | Mustard oil | Topical | Several acute applications | NA | Cutaneous lesions similar to pityriasis rosea (appeared after first application) | Corticosteroids and antihistamines | Full resolution followed by recurrence on re-exposure | Certainly | None |
|
| Walker 1984 [74] | 35 | Prosthetic aortic valve, history of myocardial infarctions with prolonged prothrombin time. Treated with warfarin and dipyridamole | Lettuce and greens (e.g., turnip, mustard greens, broccoli) | Oral | 5 weeks | Not specified. Authors do mention, however, that vitamin K intake was 6000 μg per day | Diet-induced warfarin resistance which led to substernal chest pain and myocardial infarction | Referred to hospital, where she was treated with nitroglycerin and heparin | Full resolution | Likely | Vitamin K consumption was 60 times more than the norm (360 μg) |
|
| Kempin 1983 [75] | Not given | Patient 1: pulmonary embolism; Patient 2: cardiovascular disease (not specified which). Treated with heparin and Coumadin (=warfarin) | Broccoli | Oral | Chronic (exact duration not mentioned) | Up to 450 g/day | Warfarin resistance | Coumadin anticoagulation in patient 2 | Full resolution | Likely | None |
|
| Geier 1991 [76] | 45 | Bronchitis | Home-made mustard wrap, containing ground mustard seeds and water | Topical | Acute application (20 minutes) | Not specified | Toxic irritative dermatitis | Topical corticosteroids | Full resolution | Possibly | Authors labeled case as toxic irritative dermatitis and NOT an allergic reaction and warn against use of home-made medications |
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