Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits

Table 1

Body weight, plasma lipid profiles, and inflammatory marker.

		0 weeks	6 weeks	12 weeks	16 weeks	28 weeks
Body weight (kg)	HCD	2.51±0.06	2.78±0.06	2.95±0.07	3.09±0.06	2.86±0.08 **
	Chow diet	2.63±0.05	2.98±0.06	3.05±0.05	3.15±0.05	3.54±0.06
Total cholesterol (mg/dL)	HCD	50.44±3.93	1032.56±53.2 **	810.74±64.22 **	1008.92±118.39 **	1143.82±129.62 **
	Chow diet	48.29±3.37	65.89±3.32	65.89±3.32	45.63±6.87	77.32±8.37
Triglyceride (mg/dL)	HCD	53.52±11.13	83.11±7.46	72.15±9.62	76.51±16.82	70.76±10.11
	Chow diet	80.40±18.25	99.26±23.30	92.73±24.68	98.73±29.87	86.51±10.64
HDL-C (mg/dL)	HCD	20.00±4.08	7.17±1.39 **	4.89±1.09 **	2.65±0.42 **	5.31±1.22 **
	Chow diet	21.91±1.91	17.40±2.10	17.98±1.75	17.81±2.09	16.97±1.54
pCRP (mg/dL)	HCD	16.76±3.53	38.47±10.95	81.51±27.90	155.41±20.55 **	226.10±28.55 **
	Chow diet	16.66±3.20	21.06±4.72	24.66±11.66	26.27±5.90	13.59±1.90

HCD, the group for high-cholesterol diet, 0 weeks (𝑛=10), 6 weeks (𝑛=10), 12 weeks (𝑛=11), 16 weeks (𝑛=12), 28 weeks (𝑛=11); Chow diet, the control group for normal diet, 𝑛=10; HDL-C, high-density lipoprotein-cholesterol; pCRP, plasma C-reactive protein levels. Values are expressed as mean ± SEM, *𝑃<0.05 and **𝑃<0.01 to control group.