Troglitazone Induces Extracellular Matrix and Cytoskeleton Remodeling in Mouse Collecting Duct Cells

Figure 2

Troglitazone induces morphological changes in M1 cells independent of PPARγ. Images of F-actin filaments stained with FITC-conjugated phalloidin are shown, in M1 cells stimulated for 24 hours with (a) DMSO (vehicle), (b) 10 μM GW9662 (PPARγ antagonist), (c) 5 μM troglitazone (TRO), (d) GW9662 and 5 μM TRO, (e) 10 μM TRO, and (f) GW9662 and 10 μM TRO. Magnification 100x.

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