Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Figure 1

Plots of 𝐶_max and AUC_0–∞ of cefuroxime lysine (a) and cefuroxime sodium (b) versus different drug dosages in dogs. The indicated regression equations and its interrelation coefficients (𝑟²) of 𝐶_max and AUC for cefuroxime lysine and cefuroxime sodium were calculated from the calibrated straight lines.

(a)

(b)