Research Article

Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Figure 3

The curves of mean plasma concentrations versus time for cefuroxime lysine (a) and cefuroxime sodium (b) were calibrated following 30 min of infusion The administrated drug concentrations were indicated. The plasma was obtained in different time periods. 10 μL aliquot was injected into the UPLC-MS/MS system for analysis. The values are in mean ± SD mg/L of plasma, where 𝑛 = 6 .
507294.fig.003a
(a)
507294.fig.003b
(b)