Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Table 4

The linear regression equation of cefuroxime lysine and cefuroxime sodium calculated by predicted/observed drug concentrations with a 3-compartment open model.

Dose	Cefuroxime sodium		Cefuroxime lysine
mg/kg	Regression equation	𝑅^2	Regression equation	𝑅^2
20	𝑦=0.9998𝑥+0.2175	0.9885	𝑦=0.9698𝑥+0.6396	0.9697
40	𝑦=0.9709𝑥+1.303	0.9775	𝑦=1.002𝑥−0.1707	0.9940
80	𝑦=0.9911𝑥+0.6244	0.9918	𝑦=0.9986𝑥−0.0588	0.9843