Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome

Table 2

Comparison of genotype frequencies and Hardy-Weinberg equilibrium test results of the four polymorphisms in the apolipoprotein A1/C3/A5 gene cluster between control and ACS group.

		ACS	Controls	P
		(𝑛=229)	(𝑛=254)
APOA1 −75G > A	GG	41% (94)	42.5% (108)
	GA	41.5% (95)	48.8% (124)	0.012
	AA	17.5% (40)	8.7% (22)
	G	61.8% (283)	66.9% (340)
	A	39.2% (175)	33.1% (168)	0.096
APOC3 −455T > C	TT	20% (46)	26.4% (67)
	TC	50% (115)	53.9% (137)	0.026
	CC	30% (68)	19.7% (50)
	T	73.1% (207)	82.7% (271)
	C	26.9% (251)	17.3% (237)	0.012
APOA5 −1131T > C	TT	38.9% (89)	52% (132)
	TC	39.7% (91)	33.9% (86)	0.01
	CC	21.4% (49)	14.1% (36)
	T	58.7% (269)	68.9% (350)
	C	41.3% (189)	31.1% (158)	0.001
APOA5 c.553G > T	GG	81.2% (186)	90.9% (231)
	GT	17.9% (41)	8.3% (21)	0.007
	TT	0.9% (2)	0.8% (2)
	G	90.2% (413)	95.1% (483)
	T	9.8% (45)	4.9% (25)	0.003