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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 510650, 6 pages
Research Article

Synthesis of 1,5-Benzodiazepine and Its Derivatives by Condensation Reaction Using H-MCM-22 as Catalyst

S.O.S in Chemistry, Jiwaji University, Gwalior 474011, India

Received 2 December 2011; Revised 24 January 2012; Accepted 7 February 2012

Academic Editor: Daehee Kang

Copyright © 2012 Sheikh Abdul Majid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple and versatile method for the synthesis of 1,5-benzodiazepines is via condensation of o-phenylenediamines (OPDA) and ketones in the presence of catalytic amount of H-MCM-22 using acetonitrile as solvent at room temperature. In all the cases, the reactions are highly selective and are completed within 1–3 h. The method is applicable to both cyclic and acyclic ketones without significant differences. The reaction proceeds efficiently under ambient conditions with good-to-excellent yields.