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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 516981, 10 pages
Review Article

Cancer Chemoprevention by Citrus Pulp and Juices Containing High Amounts of β-Cryptoxanthin and Hesperidin

1The Tohkai Institute of Cytopathology: Cancer Research and Prevention, 5-1-2 Minami-uzura, Gifu City, Gifu 500-8285, Japan
2Department of Tumor Pathology, Graduate School of Medicine, Gifu University, Gifu City, Gifu 501-1194, Japan
3Department of Physical Therapy, Kansai University of Health Sciences, 2-11-1 Wakaba, Kumatori-Machi, Sennan-Gun, Osaka 590-0482, Japan
4Department of Pharmacy, Kinjo Gakuin University, 2-1723 Ohmori, Moriyama-Ku, Nagoya City, Aichi 463-8521, Japan

Received 26 July 2011; Accepted 29 August 2011

Academic Editor: Masa-Aki Shibata

Copyright © 2012 Takuji Tanaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


β-Cryptoxanthin, a carotenoid, and hesperidin, a flavonoid, possess inhibitory effects on carcinogenesis in several tissues. We recently have prepared a pulp (CHRP) and citrus juices (MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ). They contain high amounts of β-cryptoxanthin and hesperidin. We have demonstrated that CHRP and/or MJs inhibit chemically induced rat colon, rat tongue, and mouse lung tumorigenesis. Gavage with CHRP resulted in an increase of activities of detoxifying enzymes in the liver, colon, and tongue rats'. CHRP and MJs were also able to suppress the expression of proinflammatory cytokines and inflammatory enzymes in the target tissues. This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs.