Insights and Hopes in Umbilical Cord Blood Stem Cell Transplantations

Table 1

Important surface markers for quantification of human umbilical cord blood content.

Human CD antigens	Cell types expressed on	CD function
CD3	T cells, thymocyte subset	With TCR, TCR surface expression/signal transduction
CD4	Thymocyte subset, T subset, monocytes, macrophages	MHC class II coreceptor, HIV receptor, T cell differentiation/activation
CD8	Thymocyte subset, T subset, NK	MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation/activation
CD11c	DC, myeloid cells, NK, B, T subset	Binds CD54, fibrinogen, and iC3b
CD17	Neutrophils, mono, platelets	Lactosylceramide
CD19	B, FDC	Complex w/CD21 and CD81, BCR coreceptor, B cell activation/differentiation
CD25	T^act, B^act, lymph progenitors	IL-2Rα, w/IL-2Rβ, and γ to form high affinity complex
CD34	Haematopoietic precursors, capillary endothelial, embryonic fibroblasts	Stem cell marker, adhesion, CD62L receptor
CD45	Haematopoietic cells, multiple isoforms from alternative splicing	Tyrosine phosphatase, enhanced TCR, and BCR signals
CD56	NK, T subset, neurones, some large granular lymphocyte leukemias, myeloid leukemias	Adhesion
CD123	Lymph subset, basophils, haematopoietic progenitors, macrophages, DC, megakaryocytes	IL-3Rα, w/CDw131
CD133	Haematopoietic stem cell subset, epithelial, endothelial	Adhesion
7ADD	Nucleic acid attachment	Apoptosis marker and viability assessment
Lin1	CD3; T-lymphocytes; CD14; monocytes, macrophages, neutrophils and eosinophils,; CD16; NK-lymphocytes, macrophages, cultured monocytes and neutrophils,; CD19/CD20; B-lymphocytes,; CD56; activated and resting NK-lymphocytes	With TCR, TCR surface expression/signal transduction.; Pattern recognition receptor; Fc receptor; B-cell coreceptor; Adhesion molecule
HLA-DR	Macrophages, B-cells and dendritic cells	MHC class II cell surface marker