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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 580687, 8 pages
Review Article

PEDF in Diabetic Retinopathy: A Protective Effect of Oxidative Stress

Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

Received 8 December 2011; Accepted 8 February 2012

Academic Editor: Takeshi Yabe

Copyright © 2012 Xiao-feng Zhu and Hai-dong Zou. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic retinopathy (DR) is a major cause of blindness in working age adults, and oxidative stress plays a vital role in the pathogenesis of DR. Pigment-epithelium-derived factor (PEDF), a multifunctional protein, has shown to inhibit the development of DR by accumulating evidence. This paper highlights the current understanding of probable mechanism about how PEDF blocks the deterioration of DR through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in DR. Gene therapy of PEDF is becoming more and more acceptable and will widely be applied to the actual treatment in the near future.