Research Article

A Novel Antihepatitis Drug, Bicyclol, Prevents Liver Carcinogenesis in Diethylnitrosamine-Initiated and Phenobarbital-Promoted Mice Tumor Model

Table 2

Levels of serum marker enzymes ALT, AST, and ALP in all groups.

GroupDosage
(mg/kg)
AST (u/L)ALT (u/L)ALP (u/L)

Control 3 3 2 . 0 ± 3 2 . 8 1 8 2 . 9 ± 2 5 . 7 5 . 3 ± 1 . 2
DEN/PB 3 3 4 . 1 ± 3 2 . 1 2 8 3 . 5 ± 5 5 . 9 ## 1 0 . 8 ± 6 . 4 #
Bicyclol100 3 2 4 . 3 ± 1 9 . 1 2 2 4 . 4 ± 2 3 . 3 ** 8 . 4 ± 4 . 3
200 3 5 0 . 5 ± 4 5 . 6 2 2 2 . 2 ± 5 3 . 8 7 . 8 ± 2 . 2

Data are means ± SD values ( 𝑛 = 8 ~10). # 𝑃 < 0 . 0 5 , # # 𝑃 < 0 . 0 1 , compared with the control group. 𝑃 < 0 . 0 1 compared with the DEN/PB model group.