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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 590384, 7 pages
Research Article

Inhibition of Streptococcus gordonii Metabolic Activity in Biofilm by Cranberry Juice High-Molecular-Weight Component

1Department of Bioscience Research, The University of Tennessee, Memphis, TN 38163, USA
2Department of Bioscience Research, The University of Tennessee Health Science Center, 711 Jefferson Avenue, Suite 426, Boling Center, Memphis, TN 38133, USA
3Department of Periodontology, The University of Tennessee, Memphis, TN 38163, USA
4Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, 61999 Tel Aviv, Israel

Received 1 July 2011; Accepted 10 October 2011

Academic Editor: Carla Pruzzo

Copyright © 2012 Jegdish Babu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous studies demonstrated that a cranberry high-molecular-mass, nondialyzable material (NDM) can inhibit adhesion of numerous species of bacteria and prevents bacterial coaggregation of bacterial pairs. Bacterial coaggregation leads to plaque formation leading to biofilm development on surfaces of oral cavity. In the present study, we evaluated the effect of low concentrations of NDM on Streptococcus gordonii metabolic activity and biofilm formation on restorative dental surfaces. We found that the NDM selectively inhibited metabolic activity of S. gordonii, without affecting bacterial viability. Inhibiting the metabolic activity of bacteria in biofilm may benefit the health of the oral cavity.