Figure 2: Association of the canonical Toll-like receptor pathway with IRF5 haplotype. Differential regulation of the TLR pathway was seen using Ingenuity analysis ( 𝑃 < 0 . 0 1 ). Unstimulated conditions are shown on the left, and EBV-exposed conditions on the right. Genes with altered expression based on haplotype are shown as either red or blue. IKB: inhibitor of NFκB, IKK: IKB kinase, JNK: c-Jun N-terminal kinase, LBP: lipopolysaccharide-binding protein, MKK: mitogen activated protein kinase kinase, NIK: NFκB inducing kinase, PPARα: peroxisome proliferator-activated receptor α, TAB1: transforming growth factor β-activated kinase 1, TIRAP: Toll/IL-1 receptor domain containing adaptor protein, and TRAF6: tumor necrosis factor receptor-associated factor 6.