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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 594056, 12 pages
Research Article

Effects of IRF5 Lupus Risk Haplotype on Pathways Predicted to Influence B Cell Functions

1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
2Department of Microbiology and Molecular Biology, Brigham Young University, 857 WIDB, Provo, UT 84604, USA
3Division of Rheumatology, Cincinnati Children’s Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
4Departments of Medicine and Pathology, The University of Oklahoma Health Sciences Center, 1100 N. Lindsay, Oklahoma City, OK 73104, USA

Received 5 May 2011; Revised 4 November 2011; Accepted 5 November 2011

Academic Editor: Timothy B. Niewold

Copyright Β© 2012 Joel M. Guthridge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplemental data contains gene sets for SLE risk or protective allele groups that were significantly enriched at p < 0.01, but did not cross the threshold of 25% FDR (Tables 1 and 2). Tables 3 and 4 include the gene sets that were enriched in the non–risk cells compared to the risk cells. Also included in the supplemental tables are all of the gene sets that were significantly enriched for each group after EBV infection (Table 5).

  1. Supplementary Material