Human Blood-Vessel-Derived Stem Cells for Tissue Repair and Regeneration

Table 1

Comparison of hBVSC subpopulations and bone marrow MSCs.

	MEC	Pericyte	AC	BM-MSC
Native location	Intima	Media	Adventitia	Bone marrow
Cell surface marker profile for cell sorting	CD34+; CD45−; CD56+; CD144+	CD34−; CD45−; CD56−; CD146+	CD31−; CD34+; CD45−; CD146−	N/A
Classic MSC marker expression in culture	CD29+; CD44+; CD90+; CD105+	CD44+; CD73+; CD90+; CD105+	CD44+; CD73+; CD90+; CD105+	CD29+; CD44+; CD73+; CD90+; CD105+
Differentiation in vitro	Osteogenic (+); Chondrogenic (+); Adipogenic (ND); Myogenic (+)	Osteogenic (+); Chondrogenic (+); Adipogenic (+); Myogenic (+)	Osteogenic (+); Chondrogenic (+); Adipogenic (+); Myogenic (ND)	Osteogenic (+); Chondrogenic (+); Adipogenic (+); Myogenic (+)
Differentiation in vivo	Myogenesis	Myogenesis Osteogenesis	Vasculogenesis	Osteogenesis; Chondrogenesis; Adipogenesis; Myogenesis; Cardiomyogenesis; Vasculogenesis
Potential clinical application	Skeletal musclerepair/regeneration; Cardiac repair	Skeletal muscle repair/regeneration; Vascular repair/regeneration	Vascular repair/regeneration; Cardiac repair	Bone repair; Cartilage repair; Tendon/ligament; repair; skeletal; muscle repair; Vascular repair; Cardiac repair; Wound healing; Immunoregulation

MEC: myogenic endothelial cell; AC: adventitial cell; BM-MSC: bone marrow mesenchymal stem/stromal cells; N/A: not available; ND: not determined.