Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses

Figure 3

Overcoming the resistance of tumor cells to CTL-mediated cytotoxic effects. (a) Targeted drugs (e.g., bortezomib) sensitize tumor cells toward CTL attack through perforin-mediated and Fas-ligand- (FasL-) based pathways. (b) Targeted drugs (e.g., PI3 K-AKT inhibitors) inhibit antiapoptotic proteins to promote cytotoxic effects.