Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 3

Detection of infectious HSV-1 from latent mice following stimulation.

Mouse strain	Gender	HSV-1 strain	Tissue/fluid/identification procedure	Frequency of detection of reactivation	Type or method of induction	Use of model	Authors, year (reference no.)
BALB/c (inbred)	Male	McKrae	Eye swabs	16/23 (70%)	Transcorneal epinephrine iontophoresis	Reactivation	Willey et al., 1984 [44]
NIH-OLA (inbred)	NA	McKrae	Eye wash	2/2 (100%)	Immunosuppressant	Reactivation antigen studies	Shimeld et al., 1990 [42]
NIH-OLA (inbred)	NA	McKrae	Eye wash	9/9 (100%)	Immunosuppressant UV-B	Reactivation antigen studies	Shimeld et al., 1990 [42]
NIH Swiss Webster	Male	17 Syn+	Eye swab	9/20 (45%)	Cx and Dx	LAT facilitates reactivation	Cook et al., 1991 [49]
NIH Swiss Webster	Male	XC-20, (LAT+)	Eye swab	6/19 (31.6%)	Cx and Dx	LAT facilitates reactivation	Cook et al., 1991[49]
NIH Swiss Webster	Male	X10-13 (LAT−)	Eye swab	1/20 (5%)	Cx and Dx	LAT facilitates reactivation	Cook et al., 1991[49]
BALB/c	Female	McKrae	Eye swab	15/28 (54%)	NaB in PBS	In vivo HSV-1 reactivation	Neumann et al., 2007 [51]
BALB/c	Female	17 Syn+	Eye swab	21/65 (32%)	NaB in PBS	In vivo HSV-1 reactivation	Neumann et al., 2007 [51]

Cx: cyclophosphamide, Dx: dexamethasone, LAT: latency-associated transcripts, NA: not available, NaB: sodium butyrate, and PBS: phosphate-balanced saline.