Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 7

Inhibitor of HSV-1 reactivation in latently infected rabbits.

HSV-1 Strain	Inhibitor	Frequency of detection of reactivation with inhibitor	Frequency of detection of reactivation without inhibitor	Authors, year (reference no.)
McKrae	Propranolol with epinephrine iontophoresis	56/84 (67%) with 20 mg/kg; 23/42 (55%) with 200 mg/kb	46/84 (55%) and 20/42 (48%)	Garza and Hill, 1997 [82]
McKrae	Propranolol with Cx and Dx	27/56 (48%)	29/63 (46%)	Garza and Hill, 1997 [82]
17 Syn+	Propranolol with epinephrine iontophoresis	43/70 (61%) with 5 mg/kg;29/56 (52%) with 200 mg/kg	34/70 (49%) and 7/8 (88%)	Garza and Hill, 1997 [82]
17 Syn+	Propranolol with Cx and Dx	24/63 (38%)	21/56 (38%)	Garza and Hill, 1997 [82]
McKrae	Propranolol	20/264 (7.6%)	28/216 (13%)	Kaufman et al., 1996 [80]
17 Syn+	Propranolol	11/336 (3.3%)	31/264 (11.7%)	Kaufman et al., 1996 [80]
McKrae	Bupropion	9/20 (45%)	13/29 (65%)	Myles et al., 2004 [89]
McKrae	Bupropion with nicotine transdermal	13/36 (36.1%)	35/36 (97.2%)	Myles et al., 2004 [89]
W strain	Alpha blockers	10/14 (71%)	13/14 (93%)	Gordon et al., 1990 [90]

Cx: cyclophosphamide and Dx: dexamethasone.