Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 8

Induced recurrent corneal lesions in HSV-1 latently infected rabbits.

HSV-1 strain	Frequency of detection of reactivation	Type or method of induction	Authors/year (reference no.)
McKrae	9/10 (90%) SPK; 1/10 (10%) dendrites; 9 epithelial ulcers	PKP	Beyer et al., 1989 [83]
McKrae	11/11 (100%) SPK; 1/11 (9%) dendrites; 9/11 (82%) epithelial ulcers	PKP plus Dx (immunosuppressant)	Beyer et al., 1989 [83]
17Syn+	5/10 (50%); 2/10 (20%) of controls	BN 52021	Beyer et al., 1989 [85]
McKrae	36/157 (23%)	0.1% 6-HD iontophoresis followed by topical 0.1% Propine	Hill et al., 1987 [116]
McKrae	20/24 (83%)	Cx and Dx	Haruta et al., 1989 [88]
McKrae	17/34 (50%)	0.01% timolol iontophoresis	Haruta et al., 1987 [10]
McKrae	7/12 (58%)	transsection at corneoscleral limbus (corneal nerve disruption)	Beyer et al., 1990 [84]

Rabbits were inoculated in the eye. Lesions were identified using slit-lamp examination. Cx: cyclophosphamide, Dx: dexamethasone, PKP: penetrating keratoplasty, and SPK: superficial punctate keratitis.