Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale
Ethanol and aqueous extracts of ginger inhibit proliferation of MCF-7 and MDA-MB-231 cells. MCF-7 (a and b), MDA MB-231 (c and d), and MCF-10A (e and f) cells were incubated with the indicated concentrations of ethanol (a, c, and e) or aqueous (b, d, and f) extract of ginger for displayed time intervals. The cell viability was measured by trypan blue dye exclusion assay, as described in Materials and Methods. The experiments were repeated five times in triplicates, and cell viabilities at each dose of ginger extracts were expressed in terms of percent of control and reported as the mean SD.