Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria

Table 1

Antibacterial activity of silibinin and antibiotics in oral bacteria.

Samples	Silibinin (μg/mL)			Ampicillin	Gentamicin
	MIC50<	MIC90<	MIC/MBC	MIC/MBC (μg/mL)
S. mutans ATCC 25175^1	0.05	0.2	0.2/0.4	0.125/0.5	8/16
S. sanguinis ATCC 10556	0.1	0.4	0.4/0.4	0.5/1	64/64
S. sobrinus ATCC 27607	0.1	0.4	0.4/0.8	0.5/1	4/8
S. ratti KCTC 3294^2	0.2	0.8	0.8/0.8	0.5/1	16/32
S. criceti KCTC 3292	0.2	0.8	0.8/1.6	1/2	8/16
S. anginosus ATCC 31412	0.1	0.8	0.8/1.6	1/2	32/32
S. gordonii ATCC 10558	0.025	0.1	0.1/0.2	0.5/1	32/32
A. actinomycetemcomitans ATCC 43717	0.4	1.6	1.6/3.2	64/64	4/8
F. nucleatum ATCC 51190	0.4	3.2	3.2/6.4	2/4	2/4
P. intermedia ATCC 49049	0.4	1.6	1.6/3.2	4/8	16/32
P. gingivalis ATCC 33277	0.1	0.4	0.4/0.8	0.5/1	256/512

¹American Type Culture Collection (ATCC).
²Korean collection for type cultures (KCTC).