BioMed Research International / 2012 / Article / Tab 2

Research Article

Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria

Table 2

Synergistic effects of the silibinin with ampicillin against oral bacteria.

StrainsAgentMIC/MBC (μg/mL)FICFICI2Outcome
AloneCombination1

S. mutans ATCC 251753Silibinin0.2/0.40.05/0.10.25/0.250.5/0.5Synergistic/synergistic
Ampicillin0.125/0.50.0312/0.1250.25/0.25
S. sanguinis ATCC 10556Silibinin0.4/0.40.1/0.20.25/0.50.5/0.75Synergistic/additive
Ampicillin0.5/10.125/0.250.25/0.25
S. sobrinus ATCC 27607Silibinin0.4/0.80.1/0.20.25/0.250.5/0.5Synergistic/synergistic
Ampicillin0.5/10.125/0.250.25/0.25
S. ratti KCTC 32944Silibinin0.8/0.80.1/0.20.125/0.250.375/0.75Synergistic/additive
Ampicillin0.5/10.125/0.50.25/0.5
S. criceti KCTC 3292Silibinin0.8/1.60.2/0.40.25/0.250.5/0.375Synergistic/synergistic
Ampicillin1/20.25/0.250.25/0.125
S. anginosus ATCC 31412Silibinin0.8/1.60.2/0.40.25/0.250.5/0.5Synergistic/synergistic
Ampicillin1/20.25/0.50.25/0.25
S. gordonii ATCC 10558Silibinin0.1/0.20.025/0.050.25/0.250.5/0.5Synergistic/synergistic
Ampicillin0.5/10.125/0.250.25/0.25
A. actinomycetemcomitans ATCC 43717Silibinin1.6/3.20.2/0.80.125/0.250.25/0.5Synergistic/synergistic
Ampicillin64/648/160.125/0.25
F. nucleatum ATCC 51190Silibinin3.2/6.40.4/1.60.125/0.250.375/0.5Synergistic/synergistic
Ampicillin2/40.5/10.25/0.25
P. intermedia ATCC 49049Silibinin1.6/3.20.2/0.80.125/0.250.375/0.75Synergistic/additive
Ampicillin4/81/40.25/0.5
P. gingivalis ATCC 33277Silibinin0.4/0.80.1/0.20.25/0.250.5/0.5Synergistic/synergistic
Ampicillin0.5/10.125/0.250.25/0.25

1The MIC and MBC of the silibinin with ampicillin.
2 The fractional inhibitory concentration index (FIC index).
3American Type Culture Collection (ATCC).
4Korean collection for type cultures (KCTC).

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