Natural Killer Cell Regulation by MicroRNAs in Health and Disease

Table 3

Summary of global miRNA-deficient or over-expression (Eri1^−/−) NK cells. *In particular, at latest stages of NK cell maturation. **In response to activating (ITAM) receptor-mediated stimulation.

	Bezman et al. [38]	Sullivan et al. [39]	Thomas et al. [40]
Cre Model	ER-Cre	hCD2-Cre	Global Knockout
Gene	Dicer^fl/fl/DGCR8^fl/fl	Dicer^fl/fl	Eri1^−/−
Effect on miRNAs	↓	↓	↑
Proliferation	↓	↓	↓
# NK Cells	↓ *	↓ *	↓ *
Survival	↓	↓	↔
IFN-γ production	↓ **	↑	↓ **
Degranulation (CD107a)	↓	↑	↔
Receptor Repertoire; Alterations	↓NKG2D	None Observed	Multiple, especially ↓Ly49H/D
MCMV Response	↔ IFN-γ production; ↓Ly49H^+ NK Cells	↑IFN-γ Production	↔ IFN-γ production; ↓Ly49H^+ NK Cells
In vitro Cytotoxicity	Not reported	Not reported	↔