Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein

Table 1

Biodistribution of ¹³¹I-SHH.

	30 min		2 Hr		5 Hr
Organ	% ID/g	% S.E.M.	% ID/g	% S.E.M.	% ID/g	% S.E.M.
Blood	5.5	0.3	3.1	1.4	2.7	0.3
Heart	1.9	0.9	1.9	0.2	0.8	0.3
Lung	4.8	0.4	2.3	0.3	2.0	0.3
Thyroid	2.2	0.0	2.0	0.3	1.4	0.3
Pancreas	2.9	0.1	2.0	0.3	1.2	0.3
Liver	55.2	4.8	30.6	2.7	21.3	4.4
Spleen	27.7	3.9	12.6	1.6	6.7	1.5
Kidney	15.1	1.6	10.3	0.3	8.6	1.5
Stomach	6.1	0.6	5.9	1.0	2.4	0.6
Sm intestine	4.1	0.2	3.6	1.0	1.6	0.2
Lg intestine	2.2	0.2	1.7	0.5	1.5	0.4
Muscle	1.2	0.1	0.9	0.2	0.5	0.3
Bone	1.9	0.2	1.7	0.2	0.8	0.3
Tumor	2.8	0.3	3.7	0.2	3.9	0.1
Tumor : muscle	2.4		4.4		8.1
Tumor : bone	1.5		2.2		4.7
Tumor : lung	0.6		1.6		2.0
Tumor : blood	0.5		1.2		1.5