Analyzing Gene Expression Profile in K562 Cells Exposed to Sodium Valproate Using Microarray Combined with the Connectivity Map Database
Table 3
Top CMAP hits correlated with gene expression signature induced by VPA.
Rank
CMAP drug
P
Mean score
Enrichment
Specificity
Percent nonnull
Function
1
Vorinostat
0.00000
0.918
0.974
0.0201
100
HDACi
2
Trichostatin A
0.00000
0.817
0.957
0.0000
96
HDACi
3
Wortmannin
0.00000
0.335
0.695
0.0065
77
PI3K inhibitor
4
Ly-294002
0.00000
0.325
0.564
0.0201
65
PI3K inhibitor
5
VPA
0.00000
0.370
0.516
0.0000
61
Anti-epileptic; HDACi; Mood stabilizer
6
Raloxifene
0.00002
0.302
0.789
0.0000
85
SERM
7
Trifluoperazine
0.00002
0.303
0.594
0.1154
68
Antipsychotic
8
Scriptaid
0.00004
0.728
0.968
0.0185
100
HDACi
9
Rifabutin
0.00004
0.802
0.967
0.0052
100
Antimycobacterial agent
10
Thioridazine
0.00008
0.260
0.486
0.2831
65
Antipsychotic
The connectivity score, similarity measurement of the gene expression profile between the query signature and that of a CMAP instance, ranges from −1 to 1. Only drugs with positive connectivity scores, which induce the expression of the query signature, are listed. HDACi: histone deacetylase inhibitor. SERM: selective estrogen receptor modulator. VPA: valproic acid.
