Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: New Way to Overcome Multidrug Resistance?

<table>Our proposed model of PPAR<i>α</i> effect on CYP2C and CYP2J (simplified): activation of PPAR<i>α</i> results in CYP2C and CYP2J expression. CYP2C and CYP2J convert arachidonic acid (AA) to EETs, which have cytoprotective function and also can serve as PPAR<i>α</i> ligand, resulting in feedback mechanism. CYP2C and CYP2J also metabolise xenobiotics.</table>

BioMed Research International

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Figure 2: Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: New Way to Overcome Multidrug Resistance? 