Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: New Way to Overcome Multidrug Resistance?

Table 2

Summary of CYP2C and CYP2J2 expression in normal adult tissues. Expression levels estimated at protein and mRNA level [23, 25].

Tissue	CYP protein	CYP mRNA
Gastrointestinal system
Salivary glands	CYP2C8, CYP2C9	CYP2C8, CYP2C18, CYP2C19, CYP2J2
Stomach	CYP2C9
Liver	CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Pancreas	CYP2C9, CYP2J2
Small intestine	CYP2C8, CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Large intestine	CYP2C8, CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Urinary system
Bladder		CYP2C8, CYP2C18, CYP2J2
Kidney	CYP2C8, CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Endocrine system
Adrenals	CYP2C8, CYP2C9	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Pituitary gland	CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2J2
Cardiovascular system
Myocardium	CYP2C9, CYP2J2	CYP2C8, CYP2J2
Lymphoid tissues
Tonsils	CYP2C8, CYP2C9
Spleen	CYP2C9	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Lymphatic nodes	CYP2C9
Thymus		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Respiratory system
Trachea		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Lung	CYP2C9, CYP2J2	CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Skin
Epidermis	CYP2C9
Mammary gland		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Reproductive system
Endometrium	CYP2C9
Ovary		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
uterus		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
placenta		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
prostate		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
testes		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Musculoskeletal system
bone marrow		CYP2C8, CYP2C18, CYP2J2
skeleton muscle		CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2