Development of Tyrosine-Based Radiotracer ^𝟗𝟗𝐦Tc-N4-Tyrosine for Breast Cancer Imaging

Table 1

In vivo tissue distribution of ^99mTc-N4-Tyrosine in normal Fischer 344 rats (𝑛=3) at 30, 120, and 240 minutes after injection.

Organ	30	MIN	120	MIN	240	MIN
Blood	0.88	±0.040	0.20	±0.018	0.17	±0.009
Heart	0.21	±0.022	0.06	±0.003	0.05	±0.003
Lung	0.50	±0.023	0.19	±0.011	0.14	±0.006
Thyroid	0.34	±0.019	0.10	±0.010	0.09	±0.006
Pancreas	0.17	±0.017	0.07	±0.012	0.05	±0.002
Liver	1.15	±0.059	0.70	±0.040	0.67	±0.044
Spleen	0.94	±0.089	0.76	±0.032	0.63	±0.051
Kidney	11.05	±0.783	12.34	±0.502	12.40	±0.405
Stomach	0.20	±0.018	0.08	±0.003	0.06	±0.002
Intestine	0.34	±0.057	0.13	±0.010	0.11	±0.006
Muscle	0.07	±0.007	0.03	±0.002	0.02	±0.001
Bone and joint	0.24	±0.021	0.15	±0.008	0.12	±0.008
Brain	0.03	±0.001	0.02	±0.001	0.01	±0.001

Each value indicates the percent of injected dose per gram of wet weight (%ID/g, 𝑛=3/time point). Each data represents mean of three measurements with standard deviation.