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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 679563, 8 pages
Research Article

Genome-Wide Analysis of mir-548 Gene Family Reveals Evolutionary and Functional Implications

1Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, China
2Department of Epidemiology and Biostatistics and Ministry of Education Key Lab for Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China

Received 16 May 2012; Accepted 25 July 2012

Academic Editor: Mouldy Sioud

Copyright © 2012 Tingming Liang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Multiple alignment of multicopy pre-miRNAs of hsa-miR-548f and their NJ tree.

Figure S2: The phenomenon of miRNA-miRNA interaction by forming miRNA:miRNA duplex.

Figure S3: A phylogenetic tree based on all pre-miRNAs of miR-548 gene family by using NJ model.

Figure S4: A functional interaction network of miRNA pairs.

  1. Supplementary Figure 1
  2. Supplementary Figure 2
  3. Supplementary Figure 3
  4. Supplementary Figure 4