Profiling of Age-Related Changes in the Tibialis Anterior Muscle Proteome of the mdx Mouse Model of Dystrophinopathy
Figure 4
Immunoblot analysis of novel marker proteins in normal versus mdx tibialis anterior muscle during aging. Shown are representative immunoblots with expanded views of antibody-decorated protein bands. Panels (a, b, c) were labeled with antibodies to the dystrophin-associated glycoprotein β-dystroglycan (β-DG), the CA3 isoform of the fibre type-specific enzyme carbonic anhydrase, and the molecular chaperone Hsp27, respectively. Lanes 1 and 2, and lanes 3 and 4, represent 8 weeks versus 22 months old normal wild type versus dystrophic mdx tibialis anterior muscle, respectively. Immuno-decorated protein bands are indicated by arrowheads.
