Table 3: Results of histopathological investigations of mice following repeated recombinant PfP0 administrations.

OrganSeverityChanges observed

Liver+++Severe swelling and derangement of cords, infiltration of mononuclear cells around the portal triad
Kidneys+++Tubular necrosis and diffuse necrotic changes along with infiltration of inflammatory cells around the necrotic area
Lungs+++ Edema, congestion, MNC infiltration, diffuse interstitial and patchy pneumonia
Heart+Mild congestion and swelling of fibres
Spleen+++Loss of lymphoid cells, replaced by connective tissue
BrainNo abnormality detected

−: negative, +: mild, +++: severe.