Figure 1: 2-DE map of the differentially expressed protein spots. The figure shows the position on the master (a) and on the preparative (b) gels of the 12 deregulated spots, according to the differential expression analysis of proteins from wild-type and FDDKI mouse synaptosomes. In (a), the deregulated spots are surrounded by a yellow border; matched spots within the preparative gel (b) are highlighted by a yellow circle, which also denotes the picking surface for the robotic spot picker. The representative image reported in (a) shows the Cy2-labelled proteins on the scanned master gel; protein spots in (b) were visualized by Sypro Ruby fluorescent staining. Mw: molecular weight; pI: isoelectric point.