Proteomic Characterization of a Mouse Model of Familial Danish Dementia

Table 1

Relative expression and nanoLC-ESI-LIT-MS/MS-based identification of differentially expressed proteins, as revealed by 2D-DIGE analysis of synaptosomal preparations.

Spot	Ratio	𝑃 value	Accession	Protein	Short name	pI/Mw theoretical (kDa)	Peptides	Sequence coverage	Mascot score
144	−1.85	0.029	P33175	Kinesin heavy chain isoform 5A	Kif5a	5.67/117	2	2	131
162	−1.53	0.049	P28738	Kinesin heavy chain isoform 5C	Kif5c	5.84/109	6	8	281
288	−1.41	0.047	P17710	Hexokinase-1	Hk1	6.44/108	10	12	407
425	−1.27	0.025	Q62108	Disks large homolog 4	Dlg4	5.56/80	3	4	116
890	1.51	0.043	P50516	V-type proton ATPase catalytic subunit A	Atp6v1a	5.42/68	5	11	323
			P63017	Heat shock cognate 71 kDa protein	Hspa8	5.37/71	7	12	264
			O08553	Dihydropyrimidinase-related protein 2	Dpysl2	5.95/62	3	6	163
891	−1.38	0.045	P50516	V-type proton ATPase catalytic subunit A	Atp6v1a	5.42/68	8	14	430
			P63017	Heat shock cognate 71 kDa protein	Hspa8	5.37/71	5	9	287
			O08553	Dihydropyrimidinase-related protein 2	Dpysl2	5.95/62	3	5	123
918	1.38	0.014	P50516	V-type proton ATPase catalytic subunit A	Atp6v1a	5.42/68	9	17	433
			O08553	Dihydropyrimidinase-related protein 2	Dpysl2	5.95/62	5	12	427
			P63017	Heat shock cognate 71 kDa protein	Hspa8	5.37/71	8	13	336
957	1.31	0.041	O08553	Dihydropyrimidinase-related protein 2	Dpysl2	5.95/62	13	31	925
			P97379	Ras GTPase-activating protein-binding protein 2	G3bp2	5.44/54	3	6	146
1043	1.35	0.026	Q8BMF4	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	Dlat	5.70/59	5	9	260
2632	−1.26	0.018	P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	Gnb1	5.60/37	6	21	361
			P62880	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	Gnb2	5.60/37	6	21	327
2872	−1.29	0.041	P63328	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ppp3ca	5.58/59	4	10	180
3391	−1.50	0.043	Q9D7X3	Dual specificity protein phosphatase 3	Dusp3	6.07/20	3	24	217