Figure 3: Effect of genistein on thoracic aorta morphological changes examined by HE staining (×100). (a) Con; (b) Met; (c) OVX + Met; (d) OVX + Met + GST. The tunica intima in OVX + Met group was seriously impaired with plenty of endothelial cell degenerated and desquamated from the wall (showed by ). Genistein could significantly improve the morphological changes of endothelium in ovariectomized HHcy rats. The tunica intima in OVX + Met + GST group was almost intact. Smooth muscle cells did not show any difference among different treatments.