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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 740295, 9 pages
http://dx.doi.org/10.1155/2012/740295
Review Article

Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular

School of Biomedical and Health Sciences, Victoria University, Building 6, St Albans, VIC 3021, Australia

Received 24 October 2011; Revised 9 March 2012; Accepted 23 March 2012

Academic Editor: Susan E. Crawford

Copyright © 2012 Vijay Chandolu and Crispin R. Dass. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cancer is becoming an increasingly common disease in which abnormal cells aggressively grow, invade, and metastasize. In this paper, we review the biological functions of PEDF (pigmented epithelium-derived factor) against cancer, with a focus on a particular type of bone cancer called osteosarcoma. PEDF is a 50 kDa glycoprotein and is a potent inhibitor of angiogenesis, via its ability to decrease proliferation and migration of endothelial cells. This paper critically examines the anticancer activities of PEDF via its role in antiangiogenesis, apoptosis-mediated tumor suppression, and increased tumor cell differentiation. Recently, an orthotopic model of osteosarcoma was used to show that treatment with PEDF had the greatest impact on metastases, warranting an evaluation of PEDF efficacy in other types of cancers.