Exogenous High-Mobility Group Box 1 Protein Injection Improves Cardiac Function after Myocardial Infarction: Involvement of Wnt Signaling Activation

Table 1

Cardiac function in SO, MI, and MI-HMGB1 group at 7 and 28 days.

		7 days		28 days
	SO	MI	MI-HMGB1	MI	MI-HMGB1
HR (bpm)	334±13	324±11	344±12	338±13	351±14
LVEF (%)	70.2±3.2	43.1±8.3 *	53.42±7.3^*#	30.33±4.6 *	50.61±7.6^*#
LVEDV (cm^2)	0.41±0.02	0.61±0.03 *	0.64±0.04 *	0.70±0.04 *	0.68±0.03 *
LVSA (cm^2)	0.23±0.03	0.41±0.04 *	0.49±0.05 *	0.53±0.02 *	0.50±0.04 *

SO, sham-operated control; MI, myocardial infarction; HR, heart rate; HMGB1, high-mobility group box 1 protein; LVEF, left ventricular ejection fraction; LVEDV, Left ventricular end-diastolic volume; LVESV, Left ventricular end-systolic volume *𝑃<0.05 versus SO group; ^#𝑃<0.05 versus MI group.