Effect of PGC-1α on Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose
Figure 1
High glucose stimulated the proliferation, migration, and inflammatory gene expression of VSMCs. VSMCs cultured in low-glucose (5.5 mmol/L) or high-glucose (25 mmol/L) complete media were deprived of serum for 24 h. In proliferation and inflammatory gene expression assays, VSMCs were stimulated by complete media for 6 h, respectively. In migration assays, VSMCs were suspended, and then low-glucose or high-glucose complete media were added to the lower compartment respectively. (a) proliferation of VSMCs, (b) migration of VSMCs, and (c) inflammatory gene expression of VSMCs (*).
