Effect of PGC-1α on Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose
Figure 2
Overexpression of PGC-1α inhibited proliferation, migration, and inflammatory gene expression of VSMCs in high glucose. VSMCs cultured in high-glucose (25 mmol/L) complete media were deprived of serum for 24 h. The cells were then treated with adenovirus infection for 48 h. (a) Proliferation of VSMCs, (b) migration of VSMCs, (c) inflammatory gene expression of VSMCs (*), and (d) Western blotting analysis for PGC-1α in VSMCs.
