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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 756426, 8 pages
http://dx.doi.org/10.1155/2012/756426
Research Article

Effect of PGC-1α on Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose

Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China

Received 15 April 2011; Revised 4 November 2011; Accepted 8 November 2011

Academic Editor: Kazim Husain

Copyright © 2012 Xiaoqiang Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Schwartz, D. deBlois, and E. R. O'Brien, “The intima. Soil for atherosclerosis and restenosis,” Circulation Research, vol. 77, no. 3, pp. 445–465, 1995. View at Google Scholar · View at Scopus
  2. M. Klouche, S. Rose-John, W. Schmiedt, and S. Bhakdi, “Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation,” Circulation, vol. 101, no. 15, pp. 1799–1805, 2000. View at Google Scholar · View at Scopus
  3. A. Faggiotto, R. Ross, and L. Harker, “Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation,” Arteriosclerosis, vol. 4, no. 4, pp. 323–340, 1984. View at Google Scholar · View at Scopus
  4. J. X. Rong, M. Shapiro, E. Trogan, and E. A. Fisher, “Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 23, pp. 13531–13536, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. K. K. Yerneni, W. Bai, B. V. Khan, R. M. Medford, and R. Natarajan, “Hyperglycemia-induced activation of nuclear transcription factor κB in vascular smooth muscle cells,” Diabetes, vol. 48, no. 4, pp. 855–864, 1999. View at Google Scholar · View at Scopus
  7. P. Puigserver, Z. Wu, C. W. Park, R. Graves, M. Wright, and B. M. Spiegelman, “A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis,” Cell, vol. 92, no. 6, pp. 829–839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. J. D. Lin, R. J. Yang, P. T. Tarr et al., “Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP,” Cell, vol. 120, no. 2, pp. 261–273, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Kawakami, M. Tsuda, S. Takahashi et al., “Transcriptional coactivator PGC-1α regulates chondrogenesis via association with Sox9,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 7, pp. 2414–2419, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. C. Yoon, P. Puigserver, G. X. Chen et al., “Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1,” Nature, vol. 413, no. 6852, pp. 131–138, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. J. C. Yoon, G. Xu, J. T. Deeney et al., “Suppression of β cell energy metabolism and insulin release by PGC-1α,” Developmental Cell, vol. 5, no. 1, pp. 73–83, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Zhang, C. Liu, L. Zhu et al., “PGC-1α inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells,” PLoS ONE, vol. 2, no. 11, Article ID e1137, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Gordon, L. G. Mohai, and S. M. Schwartz, “Induction of polyploidy in cultures of neonatal rat aortic smooth muscle cells,” Circulation Research, vol. 59, no. 6, pp. 633–644, 1986. View at Google Scholar · View at Scopus
  14. S. Miyake, M. Makimura, Y. Kanegae et al., “Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 3, pp. 1320–1324, 1996. View at Google Scholar · View at Scopus
  15. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. G. R. Grotendorst, H. E. Seppa, H. K. Kleinman, and G. R. Martin, “Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 6 I, pp. 3669–3672, 1981. View at Google Scholar · View at Scopus
  17. G. K. Owens, “Regulation of differentiation of vascular smooth muscle cells,” Physiological Reviews, vol. 75, no. 3, pp. 487–517, 1995. View at Google Scholar · View at Scopus
  18. S. G. Young and C. J. Fielding, “The ABCs of cholesterol efflux,” Nature Genetics, vol. 22, no. 4, pp. 316–318, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. S. B. Joseph, E. McKilligin, L. Pei et al., “Synthetic LXR ligand inhibits the development of atherosclerosis in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 11, pp. 7604–7609, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Yasunari, M. Kano, H. Kano, K. Yokokawa, M. Minami, and J. Yoshikawa, “Mechanisms of action of troglitazone in the prevention of high glucose- induced migration and proliferation of cultured coronary smooth muscle cells,” Circulation Research, vol. 81, no. 6, pp. 953–962, 1997. View at Google Scholar · View at Scopus
  21. T. Inoguchi, P. Li, F. Umeda et al., “High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells,” Diabetes, vol. 49, no. 11, pp. 1939–1945, 2000. View at Google Scholar · View at Scopus
  22. M. Sundaresan, Z. X. Yu, V. J. Ferrans, K. Irani, and T. Finkel, “Requirement for generation of H2O2 for platelet-derived growth factor signal transduction,” Science, vol. 270, no. 5234, pp. 296–299, 1995. View at Google Scholar · View at Scopus
  23. D. Weber, P. Seshiah, Y. Taniyama, and K. K. Griendling, “Src-dependent migration of vascular smooth muscle cells by PDGF is reactive oxygen species dependent,” Circulation, vol. 106, pp. 260–260, 2002. View at Google Scholar
  24. X. L. Chen, P. E. Tummala, M. T. Olbrych, R. W. Alexander, and R. M. Medford, “Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells,” Circulation Research, vol. 83, no. 9, pp. 952–959, 1998. View at Google Scholar · View at Scopus
  25. Y. Q. Han, M. S. Runge, and A. R. Brasier, “Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-κb transcription factors,” Circulation Research, vol. 84, no. 6, pp. 695–703, 1999. View at Google Scholar · View at Scopus
  26. D. Kukidome, T. Nishikawa, K. Sonoda et al., “Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells,” Diabetes, vol. 55, no. 1, pp. 120–127, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. J. St-Pierre, J. Lin, S. Krauss et al., “Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells,” Journal of Biological Chemistry, vol. 278, no. 29, pp. 26597–26603, 2003. View at Publisher · View at Google Scholar
  28. I. Valle, A. Alvarez-Barrientos, E. Arza, S. Lamas, and M. Monsalve, “PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells,” Cardiovascular Research, vol. 66, no. 3, pp. 562–573, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. J. St-Pierre, S. Drori, M. Uldry et al., “Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators,” Cell, vol. 127, no. 2, pp. 397–408, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. C. P. Regan, P. J. Adam, C. S. Madsen, and G. K. Owens, “Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury,” Journal of Clinical Investigation, vol. 106, no. 9, pp. 1139–1147, 2000. View at Google Scholar · View at Scopus
  31. R. Ross, “The pathogenesis of atherosclerosis: a perspective for the 1990s,” Nature, vol. 362, no. 6423, pp. 801–809, 1993. View at Publisher · View at Google Scholar · View at Scopus
  32. J. X. Rong, J. Kusunoki, P. Oelkers, S. L. Sturley, and E. A. Fisher, “Acyl-coenzymeA (CoA):cholesterol acyltransferase inhibition in rat and human aortic smooth muscle cells is nontoxic and retards foam cell formation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 1, pp. 122–127, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. B. M. Forman, B. F. Ruan, J. Chen, G. J. Schroepfer, and R. M. Evans, “The orphan nuclear receptor LXRa is positively and negatively regulated by distinct products of mevalonate metabolism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 20, pp. 10588–10593, 1997. View at Google Scholar · View at Scopus
  34. P. Costet, Y. Luo, N. Wang, and A. R. Tall, “Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor,” Journal of Biological Chemistry, vol. 275, no. 36, pp. 28240–28245, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Matsumoto, K. Hirano, S. Nozaki et al., “Expression of macrophage (Mφ) scavenger receptor, CD36, in cultured human aortic smooth muscle cells in association with expression of peroxisome proliferator activated receptor-γ, which regulates gain of Mφ-like phenotype in vitro, and its implication in atherogenesis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 4, pp. 1027–1032, 2000. View at Google Scholar · View at Scopus
  36. P. Tontonoz, L. Nagy, J. G. Alvarez, V. A. Thomazy, and R. M. Evans, “PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL,” Cell, vol. 93, no. 2, pp. 241–252, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Meerarani, E. J. Smart, M. Toborek, G. A. Boissonneault, and B. Hennig, “Cholesterol attenuates linoleic acid-induced endothelial cell activation,” Metabolism, vol. 52, no. 4, pp. 493–500, 2003. View at Publisher · View at Google Scholar · View at Scopus