Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas

Figure 1

The schematic diagram of base excision repair (BER) pathway for DNA repair throughout the cell cycle. BER is important for removing damaged bases. BER is initiated by DNA glycosylases (e.g., MPG), which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch or long-patch BER.