Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas

Table 1

MPG expression in human glioma and nonneoplastic brain tissues with different clinical-pathological features.

Clinicopathological features	No. of cases	MPG (n, %)				P
		−	+	++	+++
Human glioma tissues
WHO grade
I	18	14 (77.8)	4 (22.2)	0	0	0.002
II	14	8 (57.1)	4 (28.6)	2 (14.3)	0
III	38	4 (10.5)	19 (50.0)	13 (34.2)	2 (5.3)
IV	58	0	0	15 (25.9)	43(74.1)
Age
<55	52	7 (13.5)	11 (21.2)	14 (26.9)	20 (38.5)	NS
≥55	76	19 (25.0)	16 (21.1)	16 (21.1)	25 (32.9)
Gender
Male	76	19 (25.0)	19 (25.0)	15 (19.7)	23 (30.2)	NS
Female	52	7 (13.5)	8 (15.4)	15 (28.8)	22 (42.3)
KPS
<80	78	6 (7.7)	15 (19.2)	22 (28.2)	35 (44.9)	0.01
≥80	50	20 (40.0)	12 (24.0)	8 (16.0)	10 (20.0)
Surgery
Gross total resection	98	18 (18.4)	19 (19.4)	28 (28.6)	33 (33.7)	NS
Partial resection	24	6 (25.0)	6 (25.0)	1 (4.2)	11 (45.8)
Biopsy	6	2 (33.3)	2 (33.3)	1 (16.7)	1 (16.7)
Nonneoplastic brain tissues
Age
<55	4	3 (75.0)	1 (25.0)	0	0	NS
≥55	6	5 (83.3)	1 (16.7)	0	0
Gender
Male	6	5 (83.3)	1 (16.7)	0	0	NS
Female	4	3 (75.0)	1 (25.0)	0	0