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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 786417, 11 pages
Research Article

Evaluation of Mammary Cancer in 7,12-Dimethylbenz(a)anthracene-Induced Wister Rats by Asymmetrical Temperature Distribution Analysis Using Thermography: A Comparison with Serum CEA Levels and Histopathology

1Biomedical Engineering Department, School of Bioengineering, Faculty of Engineering and Technology, SRM University, Kanchipuram District, Tamil Nadu, Kattankulathur 603203, India
2Radiological Safety and Environmental Group, Indira Gandhi Centre for Atomic Research (IGCAR), Tamil Nadu, Kalpakkam 603 102, India
3Quality Assurance Division, Indira Gandhi Centre for Atomic Research (IGCAR), Tamil Nadu, Kalpakkam 603 102, India
4Indira Gandhi Centre for Atomic Research (IGCAR), Tamil Nadu, Kalpakkam 603 102, India

Received 16 March 2012; Revised 5 June 2012; Accepted 28 June 2012

Academic Editor: George E. Plopper

Copyright © 2012 S. P. Angeline Kirubha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Animal surface temperature profile captured using infrared camera is helpful for the assessment of physiological responses associated with the regulation of body temperature. Diagnosing breast cancer in early stage itself has a greater effect on the prognosis. In this work, asymmetrical temperature distribution analysis of chemical carcinogen 7,12-dimethyl benz(a)anthracene-induced in the lower right flank region of Wistar rats ( 𝑛 = 6 ) was carried out to test the potential of thermography in diagnosing mammary cancer and tumor growth over a period of nine weeks in comparison with histopathology results as standard. Temperature difference between the tumor induced lower right and left side of flank region was significant (with P value < 0 . 0 0 1 ), whereas in the abdomen and shoulder there was no significant difference in temperature between right and left sides. Percentage of asymmetrical temperature difference in the tumor induced lower flank region was 0.5 to 2%, whereas in the other regions it was < 0 . 5 %. Green pixel distribution in RGB color histogram was asymmetrical in the tumor induced lower flank region. Temperature reduction was observed in the tumor induced region after the seventh day of carcinogen induction. Asymmetrical thermogram analysis is the best method of diagnosing mammary cancer and for studying tumor development.