Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site

Figure 7

Residue-residue interactions identified in the four MD trajectories together with their residence times. A: ligand-free M3 trajectory in POPC; B: ligand-free M3 trajectory in POPC/POPS; C: M3-NMS complex in POPC; D: M3-NMS complex in POPC/POPS. Color scale: black, the interaction in present during the whole trajectory; grey, the interaction is present more than 50% of the trajectory; light grey, the interaction is present less than 50% of the trajectory. Residues in bold are those found in rhodopsin (Cordomi and Perez, 2007). Residues in italics are tentatively involved in the ion lock of M3R.