Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site

Table 2

Determination of the Log affinity and B_max values of M₃ WT receptor and mutant receptors: F222A and T235A. The affinity constants and ranges of Bmax values of ³H NMS at M3 WT and mutant receptors F222A and T235A expressed in COS-7 cells are shown as the log values ± standard error.

Receptors
WT M3	1900–3400		4
F222A	1213–1780		4
T235A	1734–2460		4