Research Article

Inference of Tumor Phylogenies from Genomic Assays on Heterogeneous Samples

Figure 4

Inferred copy number profiles for mixture components in the vicinity of three markers from the data of Navin et al. [14]. The 𝑥 -axis of each figure corresponds to probes within a specific marker region and the 𝑦 -axis to copy number relative to the diploid control in that region for each component. The thin solid line in each plot at value 1 shows the diploid threshold. Amplified components appear in black and nonamplified in grey. (a) Marker 1, corresponding to the amplicon at 1q32.1-1q32.2. (b) Marker 20, corresponding to the amplicon at 17q12-17q21.2.
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(a)
797812.fig.004b
(b)