Administration of Bone Marrow Derived Mesenchymal Stem Cells into the Liver: Potential to Rescue Pseudoxanthoma Elasticum in a Mouse Model (Abcc6−/−)
Figure 7
Migration of MSCs towards the hepatectomized liver through splenic vein. Cxcr4-MSCs labeled with Vybrant DiD dye were administered to Abcc6 −/−; Rag1 −/− mice via spleen 24 hours after partial hepatectomy, and the livers were examined at day 7 of transplantation for the homing of the transplanted cells. (a) Representative fluorescence images of hepatectomized mice after MSCs transplantation at Day 7 (lower panels). The images were examined from the ventral (left panels) and lateral (right panels) sides in comparison with PBS injected hepatectomized mice as negative control (upper panels). (b) Six-μm frozen sections were examined by immunofluoresence with an anti-GFP antibody, demonstrating the presence of GFP positive cells in the liver of mice at 7 days after intrasplenic transplantation.
